All the other chemicals were of analytical reagent grade. Methanol and ethanol were procured from Ranbaxy Chemicals, New Delhi, India and E-Merck (India) Ltd, Mumbai, respectively. Polyethylene glycol 400, propylene glycol, ethylenediamine tetraacetic acid, glycerin, hydrochloric acid, sodium meta bisulphite and urea were procured from S. ZP was procured from Kumud Drugs Pvt Ltd, Sangli, India. Therefore in order to facilitate its administration to non-cooperative aggressive psychotic patients to induce sleep and for arresting seizures in epileptic patients, the present study was undertaken to develop a stable and effective parenteral formulation containing ZP.

The onset of action with oral dosage forms is relatively slow.

It is also having anticonvulsant, antiaggressive and anticonflict actions in addition to its sedative and hypnotic effects. Zopiclone (ZP) is a non-benzodiazepine sedative hypnotic used for the short term treatment or management of insomnia 1. On the other hand, parenteral drug delivery systems are useful for administering drugs to non-cooperative, nauseous or unconscious patients. In spite of a few limitations such as pain on injection and inconvenient administration requiring a trained person, parenteral formulations are much widely used especially when an immediate physiologic response is needed in life-threatening emergencies and for administering those drugs that are destroyed by digestive secretions.

Batch Text Replacer 2.15 instal the new